Tranexamic Acid and Nicotinamide Combination Using Microneedling in Melasma Treatment
Abstract
This study aimed to evaluate the efficacy of the combination of 3% tranexamic acid, 3% nicotinamide, and microneedling verses Kligman's formula in reducing melanin index. This type of research is an experiment with a clinical experimental pre and post-control group study approach. The research sample consisted of 28 people. The research subjects consisted of two groups, consisting of 14 samples. Check the assessment points carried out at the beginning of use, the fourth week, the eighth week, and the twelfth week. The efficacy of the treatments was determined through the Mexameter®. The statistical analysis used the chi-square test. The p-value of < 0.05 statistically significant. The results showed that the melanin index decreased in both groups without statistically significant differences (p > 0.05). The effectiveness of decreasing the melanin index in group A occurred significantly from the eighth to the twelfth week. While the decrease in the melanin index in group B began to appear in the twelfth week. Therefore, the combination therapy of 3% tranexamic acid, 3% nicotinamide, and microneedling has the same effectiveness as the modified Kligman formula (hydroquinone 4%, tretinoin 0.05%, and fluocinolone acetonide 0.01%) in reducing the melanin index.
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Copyright (c) 2022 Rahma Tri Irfanti, Prasetyadi Mawardi, Nurrachmat Mulianto
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